Causes of Schizophrenia: Learn About This Disease So Worrying

The causes of schizophrenia remain to be still a question without answer, in spite of the extensive research that has been carried out. Some factors, however, seem to be of great relevance as, heredity, changes in the brain, increase of a substance in the brain called dopamine and life events stressful life events.

Causes of Schizophrenia Learn About This Disease So Worrying

The more we learn about the causes of Schizophrenia and their intervention, the more we can help the patients to have successful treatment.

THE IMPACT OF SCHIZOPHRENIA

The schizophrenia is a disease that is identified on a practically all over the world. Reaches people of all races, cultures, economic classes, and social and both sexes.

In regard to prevalence and incidence, schizophrenia should be considered the most important cause of psychiatric disability chronic. It is among the top ten reasons of social burden in the long term and represents between 1.5% and 2.6% of health expenditure in developed countries.

Having an impact so significant, it is only natural that in recent decades there has been a great advance, both in the treatment, either in the investigation of the causes of schizophrenia.

WHAT ARE THE CAUSES OF SCHIZOPHRENIA?

Over time there have been several attempts to explain the origin of this disease.

1. GENETIC PREDISPOSITION

Genetic studies show that there is a genetic predisposition for schizophrenia. It is considered to be a disease within the family, being the greater the risk of suffering from the pathology, the greater is the degree of kinship between the individuals. The likelihood of a person developing the disease is 0.5 to 1%, but this increases when there are family members with Schizophrenia.

In fact, about one-third of people with schizophrenia presents with a family history of the disease, as well as it is common to find relatives with the same disorder, and in greater frequency the closer is the degree of kinship.

The first-degree relatives of patients schizophrenics have a risk of developing the disease is about ten times greater than that of the general population, that is, the higher the proportion of genetic material shared, the greater the likelihood of developing schizophrenia. A child with one parent with schizophrenia has a 12% likelihood of developing the disease, while a child with both parents affected presents a probability in the order of 40%.

However, around 81% of the patients do not have any family in the first grade this pathology, which leads us to think that other factors, although they may have less influence compared to the genetic factors, may also be potential causes of schizophrenia.

Thus, the genetic predisposition for schizophrenia seems to not justify, by itself, the disease.

2. BRAIN STRUCTURE

The brain structure also appears to be one of the potential causes of schizophrenia, there is evidence that point to a change in the functioning of the brain able to cause the disabling symptoms.

However, this hypothesis requires further research in order to obtain final conclusions, since the physiological changes of schizophrenia seem to cover more than one area of the brain.

3. BIOCHEMICAL FACTORS

As to the biochemical factors, the hypothesis most often cited continues to be “hyperactive dopaminergic”, which argues that changes to the level of this neurotransmitter (dopamine) and their receptors may be one of the causes of the disease.

This hypothesis is related to the dopamine one of the neurotransmitters most famous of our nervous system, which plays multiple roles, namely at the level of behavior and cognition, voluntary movement, motivation, sleep, mood, attention and learning.

This theory is sustained by the effect of the medication used in schizophrenia, by blocking the receptors of dopamine, improves the positive symptoms of schizophrenia.

However, the mechanism of the dopamine does not explain entirely the schizophrenia and the role of other neurotransmitters are being investigated.

4. LIFE EVENTS STRESSFUL LIFE EVENTS

 

 

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